3D-QSAR studies on lipid peroxidation inhibitory activity of chromone derivatives

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Research Article: 3D-QSAR studies on lipid peroxidation inhibitory activity of chromone derivatives
ผู้เขียน/Author: ผศ.ดร.นฤมล โพธิ์ศรีทอง / Narumol Phosrithong 
Email: narumol.pho@siam.edu
สาขาวิชา/คณะ: คณะเภสัชศาสตร์ มหาวิทยาลัยสยาม กรุงเทพฯ 10160
Department/Faculty Faculty of Pharmacy,  Siam University, Bangkok 10160
Published/แหล่งเผยแพร่ Medicinal Chemistry Research, October 2016, Volume 25, Issue 10, pp 2368–2379

เอกสารอ้างอิง

Narumol Phosrithong. (2016). 3D-QSAR studies on lipid peroxidation inhibitory activity of chromone derivatives. Medicinal Chemistry Research, 25(10), pp 2368–2379.


ABSTRACT

Lipid peroxidation has been implicated in disease states such as atherosclerosis, asthma, neurodegenerative disorders, Parkinson’s disease, cancer, etc. In this study, the anti-lipid peroxidation activity for a series of chromone compounds, evaluated in vitro by ferric thiocyanate and thiobarbituric acid assays, were subjected to three-dimensional quantitative structure-activity relationship studies using comparative molecular field analysis and comparative molecular similarity indices analysis. From ferric thiocyanate assay, the best comparative molecular field analysis and comparative molecular similarity indices analysis models gave cross-validated r 2 (q 2 ) = 0.563 and 0.593 and non cross-validated r 2  = 0.974 and 0.929, respectively. The best comparative molecular field analysis and comparative molecular similarity indices analysis models derived from thiobarbituric acid assay gave q 2  = 0.558 and 0.612, and non cross-validated r 2  = 0.959 and 0.919, respectively. The generated hydrogen donor contour maps support the previously reported structure-activity relationship that the presence of a catechol moiety in ring A is essential for high potency.

Keywords:  Chromone derivatives Anti-lipid peroxidation activity 3D-QSAR CoMFA CoMSIA.


3D-QSAR studies on lipid peroxidation inhibitory activity of chromone derivatives

Faculty of Pharmacy, Siam University, Bangkok, Thailand

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