Research Article: | Self-assembly of cyclodextrin complexes: detection, obstacles and benefits |
ผู้เขียน/Author: | Chutimon Muankaew, P. Saokham, P. Jansook & T. Loftsson |
Email: | Chutimon.mua@siam.edu |
Department/Faculty | Faculty of Pharmacy, Siam University, Bangkok 10160 |
Published/แหล่งเผยแพร่ | Die Pharmazie – An International Journal of Pharmaceutical Sciences, Volume 75, Number 7, July 2020, pp. 307-312 |
Citation
Muankaew, C., Saokham, P, Jansook, P. & Loftsson, T. (2020). Self-assembly of cyclodextrin complexes: Detection, obstacles and benefits. Die Pharmazie – An International Journal of Pharmaceutical Sciences, 75(7), 307-312.
ABSTRACT
Cyclodextrins (CDs) are cyclic oligosaccharides that form water-soluble inclusion complexes of lipophilic molecules. They are commonly used as pharmaceutical excipients. Recently it has been bserved that CDs and CD complexes self-assemble in aqueous solutions to form transient clusters, nanoparticles and small microparticles. The critical aggregation concentration (cac) of the natural αCD, βCD and γCD in pure aqueous solutions is about 25, 8 and 9 mg/ml, respectively. The cac of 2-hydroxypropyl-β-cyclodextrin (HPβCD), that consists of a mixture of isomers, in pure aqueous solutions is significantly higher or about 118 mg/ml. Formation of guest/ CD complexes can increase or decrease the cac value. Due to the transient nature of the CD clusters and nanoparticles they can be difficult to detect and their presence is frequently ignored. However, formation of such particulate matter in aqueous CD solutions can lead to erroneous analytical results and product rejections during drug manufacturing. On the other hand, they have also given rise to formation of novel drug delivery systems with exceptional properties.
/ link สำรอง
Self-assembly of cyclodextrin complexes: detection, obstacles and benefits
Faculty of Pharmacy, Siam University, Bangkok, Thailand
Related
- Thromboprophylaxis in Multiple Myeloma Patients Receiving Immunomodulatory Drugs
- The Perspective of Stakeholders towards the Problems and Solutions of Health Products Available Through Social Commerce in Thailand
- Prognostic Value of Serum Procalcitonin level for the Diagnosis of Bacterial Infections in Critically-ill Patients
- Formulation and in-vitro evaluation of fast dissolving tablets using superdisintegrant blend with effervescent materia
- Doripenem dosing regimens in Asian critically ill patients with continuous real replacement therapy
- Doripenem dosing in Asian critically ill patients with continuous renal replacement therapy
- Design and characterisation of electrospun shellac-polyvinylpyrrolidone blended micro/nanofibres loaded with monolaurin for application in wound healing