Self-assembly of cyclodextrin complexes: detection, obstacles and benefits

Last modified: July 29, 2020
You are here:
Estimated reading time: 1 min
Research Article: Self-assembly of cyclodextrin complexes: detection, obstacles and benefits
ผู้เขียน/Author: Chutimon Muankaew, P. Saokham, P. Jansook & T. Loftsson
Email: Chutimon.mua@siam.edu
Department/Faculty Faculty of Pharmacy,  Siam University, Bangkok 10160
Published/แหล่งเผยแพร่ Die Pharmazie – An International Journal of Pharmaceutical Sciences, Volume 75, Number 7, July 2020, pp. 307-312

Citation

Muankaew, C., Saokham, P, Jansook, P. & Loftsson, T. (2020). Self-assembly of cyclodextrin complexes: Detection, obstacles and benefits. Die Pharmazie – An International Journal of Pharmaceutical Sciences, 75(7), 307-312.


ABSTRACT

Cyclodextrins (CDs) are cyclic oligosaccharides that form water-soluble inclusion complexes of lipophilic molecules. They are commonly used as pharmaceutical excipients. Recently it has been bserved that CDs and CD complexes self-assemble in aqueous solutions to form transient clusters, nanoparticles and small microparticles. The critical aggregation concentration (cac) of the natural αCD, βCD and γCD in pure aqueous solutions is about 25, 8 and 9 mg/ml, respectively. The cac of 2-hydroxypropyl-β-cyclodextrin (HPβCD), that consists of a mixture of isomers, in pure aqueous solutions is significantly higher or about 118 mg/ml. Formation of guest/ CD complexes can increase or decrease the cac value. Due to the transient nature of the CD clusters and nanoparticles they can be difficult to detect and their presence is frequently ignored. However, formation of such particulate matter in aqueous CD solutions can lead to erroneous analytical results and product rejections during drug manufacturing. On the other hand, they have also given rise to formation of novel drug delivery systems with exceptional properties.

  /   link สำรอง

Self-assembly of cyclodextrin complexes: detection, obstacles and benefits

Faculty of Pharmacy, Siam University, Bangkok, Thailand

Related

Tags:
Was this article helpful?
Dislike 0
Views: 36