| ชื่อบทความ: | – |
| Research Article: | Doripenem dosing in Asian critically ill patients with continuous renal replacement therapy |
| ผู้เขียน/Author: | Weerachai Chaijamorn, Punyawee Puchsaka, Sutthiporn Pattharachayakul, Taniya Charoensareerat, Nattachai Srisawat, Apinya Boonpeng, Chalermsri Pummangura |
| Email: | Weerachai.cha@siam.edu |
| สาขาวิชา/คณะ: | คณะเภสัชศาสตร์ มหาวิทยาลัยสยาม กรุงเทพฯ 10160 |
| Department/Faculty | Faculty of Pharmacy, Siam University, Bangkok 10160 |
| Published/แหล่งเผยแพร่ | Journal of Critical Care, 52, 233-236. |
เอกสารอ้างอิง
Weerachai Chaijamorn, Punyawee Puchsaka, Sutthiporn Pattharachayakul, Taniya Charoensareerat, Nattachai Srisawat, Apinya Boonpeng & Chalermsri Pummangura. (2019). Doripenem dosing regimens in Asian critically ill patients with continuous renal replacement therapy. Journal of Critical Care, 52, 233-236.
ABSTRACT
1. Introduction
Antibiotic dosing in critically ill patients with continuous renal re-placement therapy (CRRT) is still challenging. Pharmacokinetic changes in critically ill patients such as increased volume of distribution and de-creased protein binding affinity affect hydrophilic drug dosing regimens[1]. Consequently, we might prescribe inadequate doses of antimicro-bial agents in patients with CRRT [1] which can affect the morbidityand mortality associated with sepsis [2]. Requirement of loading dose and higher maintenance doses for this group of patients has been sug-gested to achieve pharmacokinetic and pharmacodynamic targets [3].Continuous renal replacement therapy has been utilizing to effec-tively remove fluid and waste products in this group of patients due to hemodynamic instability [4]. Doripenem is a water-soluble carbapenem antibiotic and commonly used for Gram negative infection in intensive care unit (ICU) [5]. It can be removed by CRRT due to small molecular weight (438.52 Da) and low volume of distribution (16.8 L) [6].The recommended dosing regimens from clinical resources are mostly from the pharmacokinetic studies in Western patients and there were a few studies conducted in Asian population [7-12]. No sug-gested doripenem dosing regimens for CRRT patients based on Asian pharmacokinetic parameters exists. This study aimed to define the opti-mal doripenem dosing regimens using pharmacokinetic parameters from Asian population and body weights of Asian critically ill patients
Keywords: Pleural effusion, Drainage, Critical care, Meta-analysis.
Doripenem dosing in Asian critically ill patients with continuous renal replacement therapy
Faculty of Pharmacy, Siam University, Bangkok, Thailand