Doripenem dosing in Asian critically ill patients with continuous renal replacement therapy

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Research Article: Doripenem dosing in Asian critically ill patients with continuous renal replacement therapy
ผู้เขียน/Author: Weerachai Chaijamorn, Punyawee Puchsaka, Sutthiporn Pattharachayakul, Taniya Charoensareerat, Nattachai Srisawat, Apinya Boonpeng, Chalermsri Pummangura
Email: Weerachai.cha@siam.edu
สาขาวิชา/คณะ: คณะเภสัชศาสตร์ มหาวิทยาลัยสยาม กรุงเทพฯ 10160
Department/Faculty Faculty of Pharmacy,  Siam University, Bangkok 10160
Published/แหล่งเผยแพร่ Journal of Critical Care, 52, 233-236.

เอกสารอ้างอิง

Weerachai Chaijamorn, Punyawee Puchsaka, Sutthiporn Pattharachayakul, Taniya Charoensareerat, Nattachai Srisawat, Apinya Boonpeng & Chalermsri Pummangura. (2019). Doripenem dosing regimens in Asian critically ill patients with continuous renal replacement therapy. Journal of Critical Care, 52, 233-236.


ABSTRACT

1. Introduction

Antibiotic dosing in critically ill patients with continuous renal re-placement therapy (CRRT) is still challenging. Pharmacokinetic changes in critically ill patients such as increased volume of distribution and de-creased protein binding affinity affect hydrophilic drug dosing regimens[1]. Consequently, we might prescribe inadequate doses of antimicro-bial agents in patients with CRRT [1] which can affect the morbidityand mortality associated with sepsis [2]. Requirement of loading dose and higher maintenance doses for this group of patients has been sug-gested to achieve pharmacokinetic and pharmacodynamic targets [3].Continuous renal replacement therapy has been utilizing to effec-tively remove fluid and waste products in this group of patients due to hemodynamic instability [4]. Doripenem is a water-soluble carbapenem antibiotic and commonly used for Gram negative infection in intensive care unit (ICU) [5]. It can be removed by CRRT due to small molecular weight (438.52 Da) and low volume of distribution (16.8 L) [6].The recommended dosing regimens from clinical resources are mostly from the pharmacokinetic studies in Western patients and there were a few studies conducted in Asian population [7-12]. No sug-gested doripenem dosing regimens for CRRT patients based on Asian pharmacokinetic parameters exists. This study aimed to define the opti-mal doripenem dosing regimens using pharmacokinetic parameters from Asian population and body weights of Asian critically ill patients

 

Keywords: Pleural effusion, Drainage, Critical care, Meta-analysis.


Doripenem dosing in Asian critically ill patients with continuous renal replacement therapy

Faculty of Pharmacy, Siam University, Bangkok, Thailand

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