Doripenem dosing regimens in Asian critically ill patients with continuous real replacement therapy

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Research Article: Doripenem dosing regimens in Asian critically ill patients with continuous real replacement therapy
ผู้เขียน/Author: Weerachai Chaijamorn a*, Punyawee Puchsaka a,1 Sutthiporn Pattharachayakul b,2, Taniya Charoensareerat a,3,  Nattachai Srisawat c,4, Apinya Boonpeng d,5, Chalermsri Pummangura a,6
Email: Weerachai.cha@siam.edu
สาขาวิชา/คณะ: คณะเภสัชศาสตร์ มหาวิทยาลัยสยาม กรุงเทพฯ 10160
Department/Faculty Faculty of Pharmacy,  Siam University, Bangkok 10160
Published/แหล่งเผยแพร่ Journal of Critical Care 52 (2019)

เอกสารอ้างอิง

Weerachai Chaijamorn a*, Punyawee Puchsaka a,1 Sutthiporn Pattharachayakul b,2, Taniya Charoensareerat a,3Nattachai Srisawat c,4, Apinya Boonpeng d,5, Chalermsri Pummangura a,6 (2019). Doripenem dosing regimens in Asian critically ill patients with continuous real replacement therapy. Journal of Critical Care 52 (2019) 233-236


ABSTRACT

Antibiotic dosing in critically ill patients with continuous renal re-placement therapy (CRRT) is still challenging. Pharmacokinetic changesin critically ill patients such as increased volume of distribution and de-creased protein binding affinity affect hydrophilic drug dosing regimens[1]. Consequently, we might prescribe inadequate doses of antimicro-bial agents in patients with CRRT [1] which can affect the morbidityand mortality associated with sepsis [2]. Requirement of loading dose and higher maintenance doses for this group of patients has been sug-gested to achieve pharmacokinetic and pharmacodynamic targets [3].Continuous renal replacement therapy has been utilizing to effec-tively remove fluid and waste products in this group of patients due tohemodynamic instability [4]. Doripenem is a water-soluble carbapenemantibiotic and commonly used for Gram negative infection in intensivecare unit (ICU) [5]. It can be removed by CRRT due to small molecular
weight (438.52 Da) and low volume of distribution (16.8 L) [6].

The recommended dosing regimens from clinical resources are mostly from the pharmacokinetic studies in Western patients and there were a few studies conducted in Asian population [7-12]. No sug-gested doripenem dosing regimens for CRRT patients based on Asianpharmacokinetic parameters exists. This study aimed to define the opti-mal doripenem dosing regimens using pharmacokinetic parameters from Asian population and body weights of Asian critically ill patients

 

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Doripenem dosing regimens in Asian critically ill patients with continuous real replacement therapy

Faculty of Pharmacy, Siam University, Bangkok, Thailand

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