|Research Article:||Formulation and in-vitro evaluation of fast dissolving tablets using superdisintegrant blend with effervescent material|
|ผู้เขียน/Author:||Noppadol Chongcherdsak, Chutima Limmatvapirat and
|สาขาวิชา/คณะ:||คณะเภสัชศาสตร์ มหาวิทยาลัยสยาม กรุงเทพฯ 10160|
|Department/Faculty:||Faculty of Pharmacy, Siam University, Bangkok 10160|
|Published/แหล่งเผยแพร่:||The International Conference and Exhibition on
Pharmaceutical Sciences and Technology 2019
“Pharmaceutical Engineering and Pharmaceutical Sciences for Human Health”
การอ้างอิง/citation (APA 6th)
Noppadol Chongcherdsak, Chutima Limmatvapirat and Sontaya Limmatvapirat. (2019). Formulation and in-vitro evaluation of fast dissolving tablets using superdisintegrant blend with effervescent material. In The International Conference and Exhibition on Pharmaceutical Sciences and Technology 2019 “Pharmaceutical Engineering and Pharmaceutical Sciences for Human Health” (p41-44). Bangkok: Silpakorn University.
The objective of this study was to formulate fast dissolving tablets (FDTs) using superdisintegrant and effervescent material. The tablets were prepared by direct compression method. The effect of superdisintegrant content was studied. The weight and hardness were controlled within the range of 500±20 mg and 50±10 N, respectively. Tableting properties including weight, thickness, diameter, friability, hardness, wetting time, water absorption ratio and in-vitro dispersion time were evaluated. As a result, the physical properties of tablets were within the required limit. As increasing the amount of sodium starch glycolate, the water absorption ratio had a tendency to increase. However, the wetting and dispersion time took more longer. By effect of adding effervescent material (tartaric acid and sodium bicarbonate), the wetting and dispersion time were lower. The time showed less than 3 min that represented a good characteristic of FDTs. This study showed that, among the designed formulations, the
formulation containing effervescent material emerges as the overall best formulation based on drug dissolving characteristics.
Keywords: Fast Dissolving Tablets, Direct Compression, Superdisintegrants, Effervescent.
Formulation and in-vitro evaluation of fast dissolving tablets using superdisintegrant blend with effervescent material
Faculty of Pharmacy, Siam University, Bangkok, Thailand