Designing electrospun shellac nanofibers with mupirocin using the Box-Behnken approach for topical wound care

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Research Article: Designing electrospun shellac nanofibers with mupirocin using the Box-Behnken approach for topical wound care
Author: Nawinda Chinatangkul, Sirikarn Pengon, Wantanwa Krongrawa, Siraprapa Chansatidkosol, Chutima Limmatvapirat and Sontaya Limmatvapirat
Email: nawinda.chi@siam.edu  ;  sirikarn.pengon@siam.edu
Department|Faculty: Faculty of Pharmacy,  Siam University, Bangkok 10160
Published: Journal of Drug Delivery Science and Technology, Volume 76, Issue 103720, 31 August 2022, Pages 1-8

Citation

Chinatangkul N., Pengon S., Chatsuwan T., Krongrawa W., Chansatidkosol S., Limmatvapirat C. and Limmatvapirat S. (2022). Designing electrospun shellac nanofibers with mupirocin using the Box-Behnken approach for topical wound care. Journal of Drug Delivery Science and Technology, 76(103720), 1-8.


ABSTRACT

This study attempted to develop shellac (SHL) nanofibers containing a topical antibiotic, mupirocin (MP), as an alternative wound healing material. The impacts of formulation and process parameters such as SHL concentration, MP content, and applied voltage on the morphology of fibers were examined based on a 33 Box-Behnken experimental design with triplicate center points. The results indicated that the amounts of polymeric SHL and encapsulated MP were considered factors affecting the morphology of fabricated fibers, including size and bead ratio. As the concentrations of SHL and MP increased, the large-sized fibers would be obtained. Meanwhile, the appearance of beads would be lessened with the enhanced amount of SHL. The excellent encapsulation of MP in SHL carrier was indicated by the high entrapment efficiency (88.12 ± 0.09% – 109.93 ± 3.23%) which might be possibly due to the ultrafine network and microporous structures of nanofibers and the good affinity of MP for entrapping between the polymeric SHL as referred to the results of the characterization study. According to the assay of antimicrobial activity, S. aureus, the leading cause of wound infection, was entirely killed since 5 min after exposure to the SHL nanofibers loaded with MP, and the regrowth of living S. aureus was not found throughout the next 6 h. Therefore, the SHL nanofibers containing MP seemed to be an effective wound dressing with high encapsulation efficiency and potential antimicrobial activity against S. aureus over a period of time.

Keywords: Shellac, Mupirocin, Box-behnken design, Nanofibers, Wound dressing.


Designing electrospun shellac nanofibers with mupirocin using the Box-Behnken approach for topical wound care

Faculty of Pharmacy, Siam University, Bangkok, Thailand

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