| Research Article: | International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease |
| Author: | R.A. Gladstone, L. Siira, O.B. Brynildsrud, D.F. Vestrheim, P. Turner, S.C. Clarke, S. Srifuengfung, R. Ford, D. Lehmann, E. Egorova, E. Voropaeva, G. Haraldsson, K.G. Kristinsson, L. McGee, R.F. Breiman, S.D. Bentley, C.L. Sheppard, N.K. Fry, J. Corander, M. Toropainen, A. Steens and The Global Pneumococcal Sequencing Consortium |
| Email: | somporn.sri@mahidol.ac.th |
| Department|Faculty: | Faculty of Pharmacy, Siam University, Bangkok 10160 |
| Published | Vaccine, Volume 40, Issue 7, 11 February 2022, Pages 1054-1060 |
Citation
Gladstone R.A., Siira L., Brynildsrud O.B., Vestrheim D.F., Turner P., Clarke S.C., Srifuengfung S.,… Wolteral N. (2022). International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease. Vaccine, 40(7), 1054-1060.
ABSTRACT
Methods : Sequence data from ST801-related outbreak isolates from Norway (n = 17), Finland (n = 11) and Northern Ireland (n = 2) were combined with invasive pneumococcal disease surveillance from the respective countries, and ST801-related genomes from an international collection (n = 41 of > 40,000), totalling 106 genomes. Raw data were mapped and recombination excluded before phylogenetic dating.
Results : Outbreak isolates were relatively diverse, with up to 100 SNPs (single nucleotide polymorphisms) and a common ancestor estimated around the year 2000. However, 19 Norwegian and Finnish isolates were nearly indistinguishable (0–2 SNPs) with the common ancestor dated around 2017.
Keywords: Streptococcus pneumoniae, Pneumococcal, Whole genome sequencing, Outbreak, ST801, Molecular epidemiology, Serotype 4, PCVs, PPV23.
International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease
Faculty of Pharmacy, Siam University, Bangkok, Thailand