| Title: | Intraperitoneal daptomycin dosing for peritonitis may be inadequate: A Monte Carlo simulation approach to optimize dosing and outcomes |
| Researcher: | Taniya Charoensareerat, Tipvilai Taweepunturat, Vipavee Rodjun, Dhakrit Rungkitwattanakul, Sutthiporn Pattharachayakul, Aroonrut Lucksiri, Chonnikan Chutkrailert, Kittiwan Suksawat, Surisara Phasaprated, Susan J Lewis, Weerachai Chaijamorn |
| Degree: | Doctor of Pharmacy Program in Pharmaceutical Care |
| Major: | Pharm.D. (Pharm.Care) |
| Faculty of study: | Pharmacy |
| Academic year: | 2568 (2025) |
| Published: | Journal of Chemotherapy 2024 Sep 24: 1-9. https://doi.org/10.1080/1120009X.2024.2407705 Click |
Abstract
A two-compartmental mathematical pharmacokinetic model with first-order elimination of patients receiving CAPD of 4 exchanges for 6 h with 2 L of dialysate used in each cycle was developed to predict daptomycin disposition in 120 h of therapy. The pharmacodynamic target was plasma AUC/MIC equal to or greater than 666. The dose that achieved at least 90% of the probability of target attainment was defined as an optimal dose. Administering intraperitoneal 300 mg daily for 1 exchange daily regimen would be sufficient to treat peritonitis with S. aureus infection with MICs of 0.25 mg/L in patients undergoing CAPD. A higher dosage may be required for infections with a higher minimum inhibitory concentration. Pharmacodynamic targets and MICs significantly contributed to daptomycin doses in this setting. Clinical validation of our recommendations is recommended.
Keywords: Daptomycin, continuous ambulatory peritoneal dialysis, Monte Carlo simulation, peritonitis, pharmacokinetics
ดร. ภญ.ธนิยา เจริญเสรีรัตน์, อ. ภญ.ทิพย์วิไล ทวีพันธุรัตน์, ดร. ภญ.วิภาวี รอดจันทร์ – Dr. Taniya Charoensareerat, Miss Tipvilai Taweepunturat, Dr. Vipavee Rodjun. 2568 (2025). Intraperitoneal daptomycin dosing for peritonitis may be inadequate: A Monte Carlo simulation approach to optimize dosing and outcomes. บทความ (Paper). วิทยาศาสตร์สุขภาพ|Health Science. เภสัชศาสตร์ (Pharmacy). เภสัชศาสตรบัณฑิต ภ.บ. (การบริบาลทางเภสัชกรรม) – Pharm.D. (Pharm.Care). หลักสูตรเภสัชศาสตรบัณฑิต สาขาวิชาการบริบาลทางเภสัชกรรม – Doctor of Pharmacy Program in Pharmaceutical Care. Bangkok: Siam University
