Oral Ulcers as an Unpredictable Adverse Reaction to Quetiapine Use in a Patient With Schizophrenia

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Research Article: Oral Ulcers as an Unpredictable Adverse Reaction to Quetiapine Use in a Patient With Schizophrenia
Author: Maytinee Srifuengfung, Thanisorn Sukakul, Chalermsri Pummangura, Somporn Srifuengfung and Natee Viravan
Email: somporn.sri@mahidol.ac.th
Department|Faculty: Faculty of Pharmacy,  Siam University, Bangkok 10160
Published Journal of Clinical Psychopharmacology Volume 42 – Issue 1 – p 103-106 doi: 10.1097/JCP.0000000000001473

Citation

Srifuengfung M., Sukakul T., Pummangura C., Srifuengfung S., Viravan N. (2022). Oral Ulcers as an Unpredictable Adverse Reaction to Quetiapine Use in a Patient With Schizophrenia. Journal of Clinical Psychopharmacology, 42(1), 103-106.


ABSTRACT

Quetiapine is a dibenzothiazepine derivative that is classified as a second-generation antipsychotic, and it is available in both immediate-release (IR) and extended-release (ER) forms. The elimination half-life of quetiapine IR and norquetiapine (active metabolite) are 6 and 12 hours, respectively.

The therapeutic dose of quetiapine inschizophrenia ranges from 300 to 800 mg/d. Quetiapine acts on various receptors, such as antagonists at dopamine receptor D2 and serotonin 5HT2c receptor. The predictable adverse reactions of antipsychotics include involuntary oral movement and dry mouth, both of which can contribute to traumatic oral ulceration. Oral ulcers can occur in 49.8 to 217.7 per 1000 person-year among antipsychotic users. However, oral ulcers that result from a nontraumatic cause are rare. There has been only 1 case report of oral lesionswith white tongue and burning mouth syndrome, and the patient was taking risperidone. Here, we report a case of oral ulcers caused by quetiapine in a Thai patient with schizophrenia.

Keywords: Quetiapine, nontraumatic, dibenzothiazepine, antipsychotics, elimination


Oral Ulcers as an Unpredictable Adverse Reaction to Quetiapine Use in a Patient With Schizophrenia

คณะเภสัชศาสตร์ มหาวิทยาลัยสยาม | Faculty of Pharmacy, Siam University, Bangkok, Thailand

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