|Research Article:||Development of Bilayer Zein-Based Matrix Tablets for Multiphasic Drug Release Kinetics|
|ผู้เขียน|Author:||Noppadol Chongcherdsak, Danuch Panchapornpon, Nawinda Chinatangkul, Chutima Limmatvapirat, Sontaya Limmatvapirat|
|Department|Faculty:||Faculty of Pharmacy, Siam University, Bangkok 10160|
|Published|แหล่งเผยแพร่:||International Conference and Exhibition on Pharmaceutical Sciences and Technology 2018 Pharmaceutical Innovation and Transitional Research for human Health, 24-25 January 2018, The Ambassador Bangkok Hotel, Bangkok, Thailand. pp. 121-123|
Noppadol Chongcherdsak, Danuch Panchapornpon, Nawinda Chinatangkul, Chutima Limmatvapirat, Sontaya Limmatvapirat. (2018). Development of bilayer zein-based matrix tablets for multiphasic drug release kinetics. In International Conference and Exhibition on Pharmaceutical Sciences and Technology 2018 Pharmaceutical Innovation and Transitional Research for human Health (pp.121-123). Bangkok: Thai Industrial Parmacist Association.
Abstract-Zein has been widely used as a film coating material for controlling the release of drug. However, the role as a matrix forming agent in tablets, especially the extended release dosage forms, was not clearly studied. The objectives of this study were to develop the bilayer tablets with multiple drug release kinetics, and to explore the effect of different zein contents on the mechanism of drug release from matrix tablets. Chlorpheniramine maleate was selected as a model drug. Matrix tablets with various amounts of zein were prepared as bilayer formulations by direct compression method. The first layer was designed for immediate release, and the second layer was aimed to provide a sustained release characteristic. Tableting properties including weight, thickness, diameter, friability, hardness and disintegration were evaluated. The dissolution assay was carried out in 0.1 N HCI (pH 1.2), phosphate buffer solutions with pH of 5.5 and 7.0, respectively. The kinetics of drug release were analyzed using various mathematical models. The results suggested that weight, thickness, diameter, hardness and friability were not significantly different among formulations and well-controlled within the desired range indicating excellent tableting properties. An increase in the amount of zein led to the increased disintegration time exhibiting extended drug release. The first layer without zeing component was completely disintegrated and dissolved within 10 min while the second layer consisting of several zein concentrations was no disintegrated. When 60%w/w or more of zein was used, the drug release profile seemed to be sustained over a period of 8 h as influencing by the gel barrier formation of aein after contacting with the aqueous media. The kinetics of drug release in 0.1 N HCI and phosphate buffer solution pH5.5 wer fitted with Highchi model, whereas the drug release profile in pH 7.0 phosphate buffer solution was followed Hixson-Crowell model. Therefore, the main mechanisms of drug release in acid and basic media were Fickian’s diffusion and tablet erosion.
Keywords: Zein, Chlorpheniramine Bilayer tablet, Sustained release, Kinetic maleate.
Development of Bilayer Zein-Based Matrix Tablets for Multiphasic Drug Release Kinetics
Faculty of Pharmacy, Siam University, Bangkok, Thailand