Evaluation of Long Cuff Nitrile Examination Gloves’ Resistance to Chemotherapy Drug Permeation

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Research Article: Evaluation of Long Cuff Nitrile Examination Gloves’ Resistance to Chemotherapy Drug Permeation
Author: Withaya Chanchai, Nipaporn Auttanate, Jitkanya Promnongsaen and Songsit Srisua
Email: withaya.cha@siam.edu
Department|Faculty: Faculty of Public Health, Department of Occupational Health and Safety, Siam University, Bangkok 10160
Published: Journal of Basic and Applied Parmacology Vol. 3 No. 2 July–December 2023 pp.O45-53

Citation

Chanchai W., Auttanate N., Promnongsaen J., & Srisua S. (2023). Evaluation of long cuff nitrile examination gloves’ resistance to chemotherapy drug permeation. Journal of Basic and Applied Parmacology, 3(2), O45-53.


ABSTRACT

Nitrile examination gloves with a long cuff are frequently used in healthcare settings considering their superior durability and resistance to punctures, tears, and chemicals. Many toxic substances, including chemotherapy medications, can be effectively protected against by wearing nitrile gloves. Following established standards, this study evaluated long-cuff nitrile gloves against chemotherapy drug permeation. These tests involved exposing the gloves to 11 different chemotherapy drugs and measuring the permeation rate over a specified duration. Powder-free nitrile exam gloves and extended cuff methods of chemical analysis with regards to standard practice permeation testing for assessing the resistance of medical gloves to permeation by chemotherapy drugs (ASTM D 6978-05) The EN455 Part 1: 2000 were used to test for single-use medical gloves. The testing of chemotherapy drugs and UV/NIS absorption spectrometry were used to measure the absorbance of test chemicals, testing how much of each chemical permeated through the specimens into the collection medium. The collection medium was circulated in a closed loop at an 11 ml/minute flow rate through the testing period. It is clear that glove users must protect against the specific chemicals or chemical mixtures they are exposed to during chemotherapy. However, the results show that long cuff 400mm full finger textured 6mil nitrile gloves protected against chemotherapy drugs during working at the point of use.

Keywords: efficacy, nitrile examination gloves, resistance, chemotherapy drug, permeation.


Evaluation of Long Cuff Nitrile Examination Gloves’ Resistance to Chemotherapy Drug Permeation

Faculty of Pharmacy, Siam University, Bangkok, Thailand

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